Fragile x syndrome what is the life expectancy

Life expectancy is not affected in people with FXS because there are usually no life-threatening health concerns associated with the condition. There have been a number of studies aimed at determining the prevalence of FXS in males and females. The agreed upon prevalence of FXS:. Intellectual disabilities in FXS include a range from moderate learning disabilities to more severe intellectual disabilities. The majority of males with Fragile X syndrome demonstrate significant intellectual disability.

No one individual will have all the features of FXS, and some features, such as a long face and macroorchidism, are more common after puberty. A small percentage of females who have the full mutation of the FMR1 gene that causes FXS will have no apparent signs of the condition—intellectual, behavioral, or physical. These females are often identified only after another family member has been diagnosed. Symptoms include intellectual disability, behavioral and learning challenges, and various physical characteristics.

Males are more frequently affected, and generally with greater severity. Some people with fragile X premutations have noticeable symptoms, and others do not. A study analyzing the employment impact and financial burden experienced by families of children with FXS found that 18 [Read scientific summary] external icon. Skip directly to site content Skip directly to page options Skip directly to A-Z link. Section Navigation. Facebook Twitter LinkedIn Syndicate.

Data and Statistics on Fragile X Syndrome. Minus Related Pages. Girls are diagnosed at an average age of 42 months. Health professionals typically diagnosed FXS about 16 months after confirming a developmental delay.

About 4 in 10 families reported that they visited a health professional at least 10 times before their child was diagnosed with FXS. Co-Occurring Conditions and Characteristics A national parent survey found that most people with FXS had been diagnosed or treated for other conditions that occur together co-occurring with FXS.

Health supervision for children with fragile X syndrome. This means that women with the premutation have an increased risk of having a child with fragile X syndrome. By contrast, the premutation in men does not expand to more than repeats as it is passed to the next generation. Men pass the premutation only to their daughters. Their sons receive a Y chromosome, which does not include the FMR1 gene. Genetics Home Reference has merged with MedlinePlus.

Learn more. The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health. Fragile X syndrome. From Genetics Home Reference. Description Fragile X syndrome is a genetic condition that causes a range of developmental problems including learning disabilities and cognitive impairment. Frequency Fragile X syndrome occurs in approximately 1 in 4, males and 1 in 8, females.

Inheritance Fragile X syndrome is inherited in an X-linked dominant pattern. Research Studies from ClinicalTrials. Annotation: Deconstructing the attention deficit in fragile X syndrome: a developmental neuropsychological approach. J Child Psychol Psychiatry. Nat Rev Dis Primers. FMR1 Disorders. Lancet Neurol. Neuroanatomical, molecular genetic, and behavioral correlates of fragile X syndrome.